Peyton Manning points out just how magnanimous he's been to Rob Lowe throughout his career.
Jimmy Carr reveals how Ralph Macchio, Rob Lowe's costar from "The Outsiders," ended up on the dais.
Accompanied by her guitar, Jewel performs a song that reveals the real reason she refused to kiss Rob Lowe on screen.
Nikki Glaser gives Jewel a new nickname and describes what she loves most about the singer's toothy grin.
Roast Master David Spade takes aim at Rob Lowe's memoir and throws shade on his acting career.
© 2016 Comedy Partners. All Rights Reserved. Comedy Central and all related titles, logos and characters are trademarks of comedy partners.