Hip-hop artist Macklemore talks about fighting opioid abuse in America with President Obama.
A YouTube star who dances to hip hop while he drives takes Daniel for a ride.
Big Jay Oakerson doesn't enjoy attending his daughter's soccer games or folding her laundry.
Big Jay Oakerson surveys the crowd and explains why he wishes he had a son instead of a daughter.
Trevor makes a plea for stronger gun regulations in the aftermath of a mass shooting in Orlando, FL.
Dan Soder isn't happy with the fact that his voice hasn't changed since he was a kid.
President Obama calls for transgender-friendly bathrooms in public schools.
For 50 years, American corporations fought to keep lead paint legal at the expense of public health.
"Black-ish" star Anthony Anderson talks about reflecting authentic African-American families on TV.
Audra McDonald faces one of the hardest questions a pregnant woman can be asked.
Desi Lydic gives new moms advice on how to deal with strangers who judge their parenting style.
Ted Cruz accidentally elbows his wife in the face after his concession speech in Indiana.
Chris Hardwick remembers how his parents told him where babies come from and wonders how fetishists explain sex to their kids.
Joe Jackson finds his key to fame and fortune.
Ellie Kemper chats about having a persona similar to her character in "Unbreakable Kimmy Schmidt."
In an effort to save the planet, Daniel Tosh explains why no one should have kids.
Natasha Leggero and Patton Oswalt explain religious liberty laws and anal sex to a puppy.
Nikki Glaser reveals why she can't imagine taking her theoretical husband's name.
Larry's 70s-era alter ego gives his freaky-deaky take on some of the most pressing issues of today.
The comics describe soon-to-be parents based on their awkward pregnancy announcement videos.