Roast Master David Spade, Pete Davidson, Jewel, Ralph Macchio and Rob Lowe himself all got their chance for some cringe-worthy burns.
Peyton Manning points out just how magnanimous he's been to Rob Lowe throughout his career.
Conservative commentator Ann Coulter reveals what she finds interesting about Rob Lowe's performance in his sex tape.
Brian Moses asks Rob Lowe why he would subject himself to this kind of treatment and finds out which roaster he's most worried about.
Brian Moses polls the red carpet to see who has the most anticipated burns of the night.
Guests and dais members tell Brian Moses what they want out of a Roast joke.
During Rob Lowe's rebuttal, he gives a graphic explanation for Ann Coulter's presence on the dais.
Accompanied by her guitar, Jewel performs a song that reveals the real reason she refused to kiss Rob Lowe on screen.
Nikki Glaser has noticed that there are a few problems with Jeff Ross dressing up as Prince.
As Rob Lowe prepares for his Roast, he gets a surprise visit from the devil (A.K.A., his former costar Amy Poehler).
Brian Moses appraises Jeff Ross's look for the Roast and learns his secret to writing a great burn.